Mieloma múltiple en Chile: pasado, presente y futuro del programa nacional de drogas antineoplásicas (PANDA). Revisión de 1.103 pacientes / Survival of 1, 103 Chilean patients with multiple myeloma receiving different therapeutic protocols from 2000 to 2016
Rev. méd. Chile
;
146(7): 869-875, jul. 2018. tab, graf
Article
Dans Espagnol
| LILACS
| ID: biblio-961473
ABSTRACT
Background:
Multiple myeloma (MM) is one of the most common malignancies found in hematology.Aim:
To describe the features of patients with MM and perform a survival analysis according to the different treatment protocols used between 2000 and 2016. Material andMethods:
Analysis of the database of the Chilean national anti-neoplastic drug program. Information was obtained from 1,103 patients, with a median age of 64.5 years (range 27-95) and a male to female ratio of 11.2.Results:
The mean overall survival (OS) of patients receiving or not receiving Thalidomide was 46 and 30 months, respectively (p < 0.01). The mean OS of patients treated before 2007 (treated with melphalan and prednisone) and between 2007 and 2012 (treated with thalidomide and dexamethasone) was 36 and 48 months respectively. In the group starting in 2013 (treated with cyclophosphamide, thalidomide and dexamethasone) the median survival had not been reached at 20 months of follow up (p = 0.01 for all comparisons). Autologous transplantation (AT) was carried out in only 18% of the eligible patients. The median OS of the patients who receive an AT had not been reached at 48 month compared with 36 month among those who did not received the procedure (p < 0.01).Conclusions:
Even though overall survival has improved with time, new drugs must be introduced in our protocols to obtain similar results to those obtained worldwide.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Protocoles de polychimiothérapie antinéoplasique
/
Myélome multiple
Type d'étude:
Guide de pratique
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adulte
/
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Chili
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2018
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Fundación Arturo López Pérez/CL
/
Hospital Barros Luco Trudeau/CL
/
Hospital Base de Puerto Montt/CL
/
Hospital Base de Punta Arenas/CL
/
Hospital Gustavo Friecke/CL
/
Hospital Juan Noé/CL
/
Hospital San Juan de Dios/CL
/
Hospital Sótero del Río/CL
/
Hospital de Coyhaique/CL
/
Hospital de Rancagua/CL
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