Farmacovigilancia activa de metoclopramida 10 mg oral en pacientes del Programa de Alivio del Dolor y Cuidados Paliativos o diabetes mellitus tipo 2 en cinco hospitales del Servicio de Salud Viña del Mar-Quillota / Extrapyramidal adverse reactions to metoclopramide: a pharmacovigilance survey
Rev. méd. Chile
;
146(7): 876-884, jul. 2018. tab, graf
Article
Dans Espagnol
| LILACS
| ID: biblio-961474
ABSTRACT
Background:
In 2013 the Chilean regulatory sanitary agency issued a warning concerning dose adjustment and use restriction to avoid severe adverse effects of metoclopramide such tardive dyskinesia.Aim:
To study dyskinesia type adverse effects in a population using metoclopramide. Material andMethods:
A cross sectional observational study was conducted among patients pertaining to palliative care and diabetes mellitus programs and consuming 10 mg/day or more of metoclopramide. Patients were interrogated looking for extrapiramidal signs and symptoms using a questionnaire validated by two neurologists.Results:
In 40% of diabetic patients with gastroparesia and 35% of palliative care patients, extrapyramidal adverse reactions to metoclopramide were suspected. Palliative Care patients suffered the largest number of adverse events. The period of use and individual doses of the drug were largely above Chilean regulatory agency recommendations in all cases.Conclusions:
A significant number of patients using metoclopramide could experience extrapyramidal adverse reactions.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Douleur
/
Diabète de type 2
/
Antagonistes du récepteur D2 de la dopamine
/
Métoclopramide
Type d'étude:
Étude observationnelle
/
Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Amérique du Sud
/
Chili
langue:
Espagnol
Texte intégral:
Rev. méd. Chile
Thème du journal:
Médicament
Année:
2018
Type:
Article
Pays d'affiliation:
Chili
Institution/Pays d'affiliation:
Hospital Doctor Gustavo Fricke/CL
/
Hospital La Calera/CL
/
Hospital La Ligua/CL
/
Hospital Quilpué/CL
/
Hospital de Quillota/CL
/
Hospital de Quintero/CL
/
Servicio de Salud Viña del Mar-Quillota/CL
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