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Association of synaptosomal-associated protein 25 (SNAP-25) gene polymorphism with temperament and character traits in women with fibromyalgia syndrome
Dogru, Atalay; Balkarli, Ayse; Tepeli, Emre; Aydin, Emel; Cobankara, Veli.
Affiliation
  • Dogru, Atalay; Dr. Ersin Arslan Training and Research Hospital. Department of Internal Medicine. Division of Rheumatology. Gaziantep. TR
  • Balkarli, Ayse; Antalya Training and Research Hospital. Department of Internal Medicine. Division of Rheumatology. Antalya. TR
  • Tepeli, Emre; Pamukkale University. Department of Medical Biology. Denizli. TR
  • Aydin, Emel; Pamukkale University. Department of Psychiatry. Denizli. TR
  • Cobankara, Veli; Pamukkale University. Department of Internal Medicine. Division of Rheumatology. Denizli. TR
Arch. Clin. Psychiatry (Impr.) ; Arch. Clin. Psychiatry (Impr.);45(4): 88-93, July-Aug. 2018. tab
Article de En | LILACS-Express | LILACS | ID: biblio-961988
Bibliothèque responsable: BR1.1
ABSTRACT
Abstract

Background:

Synaptosomal-associated protein 25 (SNAP-25) may be contribute to the pathogenesis of fibromyalgia Syndrome (FMS) by affecting the release of neurotransmitters.

Objectives:

We aimed to investigate the relationship between the SNAP-25 gen (DdeI = rs1051312 and MnlI = rs3746544) polymorphism and the temperament and character traits.

Methods:

A total of 85 female patients diagnosed with FMS and 70 age-matched healthy female subjects were enrolled into the study. The Temperament and Character Inventory (TCI) were performed on all the patients. SNAP-25 gene polymorphism was determined in the patients group and controls group.

Results:

No significant difference between groups was found regarding the distribution of SNAP-25 MnlI polymorphism (p > 0.05), but it was seen that the frequency of TC genotype for DdeI gene was higher in the patients group (p < 0.05). Increased hazard avoidance was found in the patients group (p < 0.05). When TCI scores were assessed in terms of SNAP-25 gene polymorphism, no statistically significant relationship was detected between the TT, TG, GG genotypes for MnlI gen and TCI scores (p > 0.05). However, increased hazard avoidance was detected in patients with TC genotype for DdeI gene compared to patients without such genotype.

Discussion:

SNAP-25 might be an etiological factor in FMS pathogenesis and might affect personality traits of FMS patients by mediating neurotransmitter release.
Mots clés

Texte intégral: 1 Indice: LILACS Type d'étude: Risk_factors_studies langue: En Texte intégral: Arch. Clin. Psychiatry (Impr.) Thème du journal: PSIQUIATRIA Année: 2018 Type: Article

Texte intégral: 1 Indice: LILACS Type d'étude: Risk_factors_studies langue: En Texte intégral: Arch. Clin. Psychiatry (Impr.) Thème du journal: PSIQUIATRIA Année: 2018 Type: Article