Role of moxifloxacin-dexamethasone in cardiac histomorphometric findings among Wistar rats from infected mothers
Acta cir. bras
;
33(9): 744-752, Sept. 2018. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-973504
ABSTRACT
Abstract Purpose:
To investigate cardiac changes in young rats, whose mothers underwent autogenic fecal peritonitis, during organogenesis phase and to evaluate the role of intravenous administration of moxifloxacin and dexamethasone in preventing infection-related cardiac changes.Methods:
A prospective histomorphometric study was performed on 29 hearts of Wistar four-month old rats. Animals were divided into three groups Negative Control Group (NCG) included 9 subjects from healthy mothers; Positive Control Group (PCG) included 10 subjects from mothers with fecal peritonitis (intra-abdominal injection of 10% autogenic fecal suspension in the gestational period) and did not receive any treatment; and Intervention Group (IG), with 10 animals whose infected mothers received moxifloxacin and dexamethasone treatment 24 hours after induction of fecal peritonitis.Results:
Nuclear count was higher in the IG group as compared to PCG (p = 0.0016) and in NCG as compared to PCG (p = 0.0380). There was no significant difference in nuclear counts between NCG and IG.Conclusion:
Induced autogenic fecal peritonitis in pregnant Wistar rats determined myocardial changes in young rats that could be avoided by the early administration of intravenous moxifloxacin and dexamethasone.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Péritonite
/
Dexaméthasone
/
Fluoroquinolones
/
Myocarde
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Animaux
/
Grossesse
langue:
Anglais
Texte intégral:
Acta cir. bras
Thème du journal:
Chirurgie générale
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2018
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
UFPE/BR
/
Universidade Estadual de Campinas/BR
/
Universidade Federal de Pernambuco/BR
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