Viral detection profile in children with severe acute respiratory infection
Braz. j. infect. dis
;
22(5): 402-411, Sept.-Oct. 2018. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-974242
ABSTRACT
ABSTRACT Objectives:
The role of viral co-detection in children with severe acute respiratory infection is not clear. We described the viral detection profile and its association with clinical characteristics in children admitted to the Pediatric Intensive Care Unit (PICU) during the 2009 influenza A(H1N1) pandemic.Method:
Longitudinal observational retrospective study, with patients aged 0-18 years, admitted to 11 PICUs in Rio de Janeiro, with suspected H1N1 infection, from June to November, 2009. The results of respiratory samples which were sent to the Laboratory of Fiocruz/RJ and clinical data extracted from specific forms were analyzed.Results:
Of 71 samples, 38% tested positive for H1N1 virus. Of the 63 samples tested for other viruses, 58 were positive influenza H1N1 (43.1% of positive samples), rhinovirus/enterovirus (41.4%), respiratory syncytial vírus (12.1%), human metapneumovirus (12.1%), adenovirus (6.9%), and bocavirus (3.5%). Viral codetection occured in 22.4% of the cases. H1N1-positive patients were of a higher median age, had higher frequency of fever, cough and tachypnea, and decreased leukometry when compared to H1N1-negative patients. There was no difference in relation to severity outcomes (number of organic dysfunctions, use of mechanical ventilation or amines, hospital/PICU length of stay or death). Comparing the groups with mono-detection and co-dection of any virus, no difference was found regarding the association with any clinical variable.Conclusions:
Other viruses can be implicated in SARI in children. The role of viral codetection has not yet been completely elucidated.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Virus
/
Syndrome respiratoire aigu sévère
/
Grippe humaine
/
Sous-type H1N1 du virus de la grippe A
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Enfant
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Bébé
/
Mâle
/
Nouveau-né
Pays comme sujet:
Amérique du Sud
/
Brésil
langue:
Anglais
Texte intégral:
Braz. j. infect. dis
Thème du journal:
Maladies transmissibles
Année:
2018
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Fundação Oswaldo Cruz (Fiocruz)/BR
/
Instituto D'Or de Pesquisa e Ensino (IDOR)/BR
/
Universidade Federal do Rio de Janeiro (UFRJ)/BR
/
Universidade Federal do Rio de Janeiro/BR
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