Computational drug discovery for the Zika virus
Braz. J. Pharm. Sci. (Online)
;
54(spe): e01002, 2018. graf
Article
Dans Anglais
| LILACS
| ID: biblio-974426
ABSTRACT
Few Zika virus (ZIKV) outbreaks had been reported since its first detection in 1947, until the recent epidemics occurred in South America (2014/2015) and expeditiously became a global public health emergency. This arbovirus reached 0.5-1.3 million cases of ZIKV infection in Brazil in 2015 and rapidly spread in new geographic areas such as the Americas. Despite the mild symptoms of the Zika fever, the major concern is related to the related severe neurological disorders, especially microcephaly in newborns. Advances in ZIKV drug discovery have been made recently and constitute promising approaches to ZIKV treatment. In this review, we summarize current computational drug discovery efforts and their applicability to discovery of anti-ZIKV drugs. Lastly, we present successful examples of the use of computational approaches to ZIKV drug discovery.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Conception assistée par ordinateur
/
Découverte de médicament
/
Virus Zika
langue:
Anglais
Texte intégral:
Braz. J. Pharm. Sci. (Online)
Thème du journal:
Farmacologia
/
Teraputica
/
Toxicologia
Année:
2018
Type:
Article
Pays d'affiliation:
Brésil
/
États-Unis d'Amérique
Institution/Pays d'affiliation:
Collaborations Pharmaceuticals/US
/
Federal University of Goiás/BR
/
Instituto Oswaldo Cruz/BR
/
Rutgers University-New Jersey Medical School/US
/
University of North Carolina/US
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS