Influence of exposure and vertical transmission of HIV-1 on the neuropsychomotor development in children
Rev. Soc. Bras. Med. Trop
;
52: e20180263, 2019. tab
Article
Dans Anglais
| LILACS
| ID: biblio-977112
ABSTRACT
Abstract INTRODUCTION:
Exposure to human immunodeficiency virus (HIV)-1 during pregnancy is a major risk factor for neurodevelopmental delay and deleterious effects in children. However, limited information about these conditions exists in poor geographical areas in Brazil. Prevention of vertical transmission of HIV-1 is dealt differently in different regions of the country and in poorer areas it is more difficult to evaluate the impact of the prevention methods. The outcomes of the exposure to HIV-1 and the impact of vertical HIV-1 transmission on neuropsychomotor development was evaluated for the first time in children born to HIV-infected mothers in the North region of Brazil, where the majority of the population has poor access to health services.METHODS:
Sixty children born to HIV-1-infected mothers (case group) and 58 born to non-infected mothers (control group) were followed for the first 12 months of life in a prospective case-control study. Neuropsychomotor development was assessed using the Denver II test.RESULTS:
Suspected neuropsychomotor developmental delays were more frequent in the case group (33.3%), namely in language (38.9%) and gross motor skills (27.8%). These delays were reversed in most children after 12 months of life due to therapeutic intervention. The delays were not reversed in three children, all of whom belonged to the case group. Only one of these was infected with HIV-1, and this child had the poorest neuropsychomotor outcomes.CONCLUSIONS:
Maternal HIV-1 infection negatively affected the neuropsychomotor development in children, although other factors may have played a role.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Complications infectieuses de la grossesse
/
Infections à VIH
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Incapacités de développement
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Transmission verticale de maladie infectieuse
Type d'étude:
Etude d'étiologie
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Étude observationnelle
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Facteurs de risque
Limites du sujet:
Adolescent
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Femelle
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Humains
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Bébé
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Mâle
/
Grossesse
langue:
Anglais
Texte intégral:
Rev. Soc. Bras. Med. Trop
Thème du journal:
Médecine tropicale
Année:
2019
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Universidade Federal do Pará/BR
/
Universidade do Estado do Pará/BR
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