Expressions of transforming growth factor ß1 signaling cytokines in aortic dissection
Rev. bras. cir. cardiovasc
;
33(6): 597-602, Nov.-Dec. 2018. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-977471
ABSTRACT
Abstract Objective:
To demonstrate the underlying mechanisms of aortic dissection compared to those of coronary artery disease in terms of the transforming growth factor-beta (TGF-β) signaling pathway.Methods:
Twenty consecutive aortic dissection patients and 20 consecutive coronary artery disease patients undergoing a surgical treatment in this hospital were enrolled into this study. The aortic tissues were sampled and the TGF-β1 and its receptor TGF-β receptor I (TβRI) were detected by Western blotting assay.Results:
TGF-β1 and TβRI were positively expressed in the aortic tissues in both groups by Western blotting assay. The expressions of the two proteins were significantly higher in the aortic tissue of patients with aortic dissection than in those with coronary artery disease. The quantitative analyses of the relative gray scales of the proteins disclosed close correlations between the expressions of TGF-β1 and TβRI in both the study and control group patients.Conclusions:
The aortic remodeling of aortic dissection might differ from that of coronary artery atherosclerosis concerning the nature, mechanism, mode, and activities of TGF-β signaling pathway. The development of aortic dissection could be associated with a significantly enhanced function of TGF-β1/Smad signaling transduction as a result of aortic remodeling incorporating both vascular injury and repair.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Maladie des artères coronaires
/
Facteur de croissance transformant bêta-1
/
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Rev. bras. cir. cardiovasc
Thème du journal:
Cardiologie
/
Chirurgie générale
Année:
2018
Type:
Article
Pays d'affiliation:
Chine
Institution/Pays d'affiliation:
Fujian Medical University/CN
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