Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study
Braz. j. med. biol. res
;
52(2): e7773, 2019. tab, graf
Article
Dans Anglais
| LILACS
| ID: biblio-984030
ABSTRACT
The aim of this study was to evaluate the therapeutic effects of ultrasound (US)-mediated phonophoresis alone or in association with diclofenac diethylammonium (DCF) administered topically in animal models of inflammation. A pre-clinical, prospective, and randomized experimental study of quantitative and qualitative nature was carried out. Phonophoresis was performed using a therapeutic ultrasound apparatus in two distinct models of acute inflammation. Edema was induced by an intraplantar injection of carrageenan and measured by plethysmography. The Hargreaves test was used to evaluate the antinociceptive activity and investigate the action of phonophoresis on tumor necrosis factor (TNF)-α production. A histological analysis with hematoxylin-eosin was used to evaluate tissue repair, and the expression of COX-2 was determined by immunohistochemical analysis. At the peak of inflammatory activity (3 h), treatment with US, US+DCF, and DCF significantly reduced edema formation compared to the control group. Treatment with US+DCF was more effective than treatment with US alone at both analyzed times. In the analysis of the antinociceptive activity, the treatments significantly increased the latency time in response to the thermal stimulus. Histopathological analysis revealed a reduction of the inflammatory infiltrates and immunohistochemistry demonstrated that the association was effective in reducing COX-2 expression compared to the control group. The association of DCF with US produced anti-inflammatory and antinociceptive effects in rat models of inflammation, which may be associated with inhibition of COX-2 and TNF-α production.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Phonophorèse
/
Anti-inflammatoires non stéroïdiens
/
Diclofenac
/
Analgésiques
/
Inflammation
/
Anti-inflammatoires
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Recherche qualitative
/
Facteurs de risque
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Braz. j. med. biol. res
Thème du journal:
Biologie
/
Médicament
Année:
2019
Type:
Article
Pays d'affiliation:
Brésil
Institution/Pays d'affiliation:
Faculdade de Medicina Estácio de Juazeiro do Norte/BR
/
Faculdade de Medicina do ABC/BR
/
Universidade Federal Rural de Pernambuco/BR
/
Universidade Federal de Campina Grande/BR
/
Universidade Federal de Cariri/BR
/
Universidade Federal do Ceará/BR
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