Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice
Acta cir. bras
; 34(2): e201900205, 2019. tab, graf
Article
de En
| LILACS
| ID: biblio-989052
Bibliothèque responsable:
BR1.1
ABSTRACT
Abstract Purpose:
To evaluate the impact of the combination of BRL 37344 and tadalafil (TDF) on the reduction of overactive bladder (OB) symptoms.Methods:
Thirty mice were randomized into 5 groups (G) of 6 animals each. L-NAME was used to induce DO. G1 Control; G2 L-NAME; G3 L-NAME + TDF; G4 L-NAME + BRL 37344; G5 L-NAME + TDF + BRL 37344. After 30 days of treatment, the animals were submitted to cystometry to evaluate non-voiding contractions (NVC), threshold pressure (TP), baseline pressure (BP), frequency of micturition (FM) and threshold volume (TV). Differences between the groups were analyzed with ANOVA followed by the Tukey test.Results:
NVC increased in G2 (4.33±2.58) in relation to G1 (1.50±0.55). NVC decreased in G3 (2.00±1.10), G4 (1.50±1.52) and G5 (2.00±1.26) compared to G2 (p<0.05). FM decreased in G3 (0.97±0.71), G4 (0.92±0.38) and G5 (1.05±0.44) compared to G2 (p<0.05). However, the combination of TDF and BRL37344 was not more effective at increasing NVC and improving FM than either drug alone. The five groups did not differ significantly with regard to TV.Conclusion:
The combination of BRL 37344 and TDF produced no measurable additive effect on reduction of OB symptoms.Mots clés
Texte intégral:
1
Indice:
LILACS
Sujet Principal:
Éthanolamines
/
Vessie hyperactive
/
Agents urologiques
/
Tadalafil
Type d'étude:
Diagnostic_studies
Limites du sujet:
Animals
langue:
En
Texte intégral:
Acta cir. bras
Thème du journal:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Année:
2019
Type:
Article