Is there any association between osteoporotic vertebral fracture and vitamin K epoxide reductase complex subunit-1 polymorphism in Turkish society? A pilot study
Clinics
;
74: e739, 2019. tab
Article
Dans Anglais
| LILACS
| ID: biblio-989646
ABSTRACT
OBJECTIVE:
In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated.METHOD:
DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method.RESULT:
At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study.CONCLUSION:
There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.
Texte intégral:
Disponible
Indice:
LILAS (Amériques)
Sujet Principal:
Polymorphisme génétique
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Ostéoporose post-ménopausique
/
Fractures du rachis
/
Fractures ostéoporotiques
/
Vitamin K epoxide reductases
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Clinics
Thème du journal:
Médicament
Année:
2019
Type:
Article
Pays d'affiliation:
Turquie
Institution/Pays d'affiliation:
Aksaray University/TR
/
Eskişehir State Hospital/TR
/
Eskisehir Osmangazi University/TR
/
Istanbul Aydin University/TR
/
Kutahya Health Sciences University/TR
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