Studies of some Egyptian medicinal plants as natural wealth in regression of hepatocellular carcinoma [HCC]
Egyptian Pharmaceutical Journal [National Research Center]. 2008; 7 (2): 201-216
Dans Anglais
| IMEMR
| ID: emr-100909
ABSTRACT
The present investigation was designed to valuate the antiangiogenic efficacy of some local medicinal plants against liver cancer induced by diethylnitrosamine [DEN] methanolic extracts of cupressus sempervirens, chelidonium majus and tropaeolum majus were used in this study. Vascular endothelial growth factor [VEGF], alpha-Feto-protein [AFP], ferritin, alanine transaminase [ALT], aspartate transaminase [AST], Alkaline phosphatase [ALP], superoxide dismutase [SOD] and Glutathione peroxidase [GPx] were determined in blood while Nitric oxide [NO] was determined in liver tissue homogenate. Furthermore histopathological investigations ere done. The results showed that the treatment with methanolic extracts of all selected plants led to a significant reduction in the level of all the desired biochemical parameters, while the administration of cupressus sempervirens only improved the histopathological pictures of liver architecture. These results suggest a beneficial effect of these plant extracts against experimentally-induced hepatocellular carcinoma and the possible mechanism of the protective effects may be partly due to the antioxidant activity of these plants
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Indice:
Méditerranée orientale
Sujet Principal:
Aspartate aminotransferases
/
Alphafoetoprotéines
/
Carcinome hépatocellulaire
/
Inhibiteurs de l'angiogenèse
/
Chelidonium
/
Cupressus
/
Tropaeolum
/
Facteur de croissance endothéliale vasculaire de type A
/
Alanine transaminase
/
Foie
langue:
Anglais
Texte intégral:
Egypt. Pharm. J. [NRC]
Année:
2008
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