Suspected cardiotoxicity of clarithromycin in critically ill patients
Anaesthesia, Pain and Intensive Care. 2009; 13 (1): 28-30
Dans Anglais
| IMEMR
| ID: emr-101182
ABSTRACT
Clarithromycin, a macrolide antibiotic is known to have an arrhythmogenic potential in the presence of comparable QT prolongation. Indeed, the extent of QT prolongation has been used as a surrogate marker for cardiotoxicity and sudden cardiac death. We report a case series of three adult patients who were transferred to our intensive care unit [ICU] at Peradeniya Teaching Hospital, Peradeniya [Sri Lanka], and needed inotropic support and mechanical ventilation. All the three of them were treated with a standard dose regimen of intravenous clarithromycin for suspected atypical pneumonia, after which they dramatically deteriorated and unexpectedly died within 72 hours. In the absence of other known precipitating factors, cardiotoxicity of clarithromycin was suspected as the main causative factor for these deaths
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Indice:
Méditerranée orientale
Sujet Principal:
Pneumopathie infectieuse
/
Littérature de revue comme sujet
/
Torsades de pointes
/
Maladie grave
/
Tachycardie ventriculaire
/
Électrocardiographie
/
Cardiotoxines
/
Unités de soins intensifs
Type d'étude:
Enquête cas-témoins / Études cas/témoins
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Anaesth. Pain Intensive Care
Année:
2009
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