Anaplastic transformation of differentiated thyroid carcinoma

ABSTRACT

Anaplastic thyroid cancer [ATC] is one of the most aggressive malignancies that arise from transformation of preexisting differentiated thyroid cancer [DTC]. However, the carcinogenic mechanism of anaplastic transformation remains unclear. We describe a case for huge goiter diagnosed as papillary thyroid carcinoma, which underwent thyroidectomy. The final histology showed anaplastic transformation. The clinical and possible etiological aspects are discussed