Novel thienyl-substituted pyridone and pyridine derivatives, synthesis and antimicrobial activity

ABSTRACT

A novel series of thienyl-substituted pyridone and pyridine derivatives was synthesized. Treatment of arylidene alpha- acetothienones [I] with ethyl cyanoacetate afforded thienyl substituted cyanodihydropyridones [II] or cyanopyridones [III] depending on the reaction conditions. Likewise, reacting the same chalcone analogues [I] with malononitrile yielded thienyl substitued cyanoaminodihydropyridines [IV] or pyridines [V]. Some of the prepared compounds showed antimicrobial activity against S. aureus and M. phllei