Gene frequency and linkage disequilibrium within the HLA-DRB region in Egyptians using PCR-based reversed hybridization oligonucleotide genotyping
Journal of the Egyptian National Cancer Institute. 1997; 9 (1): 69-74
Dans Anglais
| IMEMR
| ID: emr-106401
ABSTRACT
HLA class II alleles were studied in 278 Egyptians. Gene frequency as well as linkage [haplotypic association] between HLA-DRB1, HLA- DRB3, HLA-DRB4 and HLA-DRB5 types were defined. A new unexpected haplotype linked with DRB5 was also detected. It was concluded that PCR based reversed hybridization genotyping is a reliable technique for DNA- based HLA-DR typing. In addition, this specific population study has important implications for unrelated bone marrow and other organ donor registries in Egypt
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Indice:
Méditerranée orientale
Sujet Principal:
Antigènes HLA-DR
/
Déséquilibre de liaison
/
Réaction de polymérisation en chaîne
/
Hybridation génétique
/
Hybridation d'acides nucléiques
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
J. Egypt. Natl. Cancer Inst.
Année:
1997
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