Effects of praziquantel [biltricide] on healthy miceI- Haematological study

ABSTRACT

In order to detect the possible adverse effects of praziquantel, 40 healthy mice were used in the experiment. Each one was given the drug at a dose of 40 mg per kg body weight orally by stomach tube. Hematological investigations as determination of hemoglobin concentration, hematocrit percent and total erythrocytic count were done at intervals of 24 hours after drug administration, 72 hours an at the end of each week for 6 weeks. Five mice were used as a comparative control group. The results obtained revealed that the host developed macrocytic hypochromic type of anemia with transient polycythemia at the end of 1s week then developed macrocytic hypochromic anemia from the end of 2nd week onwards