Influence of zinc pretreatment on lymphocyte transformation during cadmium exposure in rats

ABSTRACT

The present study shows that in vivo exposure of rats to a lethal dose of cadmium [96 hours LD 50] significantly diminished lymphocyte blastogenic transformation by PHA, in the whole blood and spleen. pre-treatment with zinc [131.25 mg Zn+**2 /kg] protected rats from the inhibitory effect of Cd administered 24 hours later, as lymphocyte blastogenic transformation values recorded were changed when compared with controls