Titrimetric determination of ethchlorvynol [placidyl] by n-bromosuccinimide and identification of the reaction products

Two simple titrimetric procedures are described for the direct and indirect determination of ethchlorvynol [placidyl] using N- bromosuccinimide [NBS]. The first procedure based on direct titration of the concerned compound dissolved in ethanol using methyl red as indicator. While the second procedure based on the addition of a known excess of standard NBS solution and back titration of the excess NBS using sodium thiosulfate. The molar ratios in both cases are found to be 1:1 of NBS: the compound. The mean percentage accuracies are found to be 99.7 + 0.532 and 101.4 + 0.839 for the direct and indirect procedures, respectively. Applying the suggested procedures to capsules containing the concerned compound indicates that the two procedures still hold their accuracies and precision as compared with the pharmacopeia procedure. To investigate the pathway of the reaction, the reaction products are extracted, separated, isolated and identified using the different physical and spectroscopic data, only one brominated product is identified in addition to the expected product succinimide. The pathway of the reaction is also suggested