Oximes in heterocyclic synthesis: synthesis of ethyl 3-methyl-5-substituted isoxazol-4-carboxylate derivatives
Egyptian Journal of Chemistry. 1996; 39 (3): 249-58
Dans Anglais
| IMEMR
| ID: emr-107757
ABSTRACT
Oxime of ethyl-3-oxobutanate [1] reacts with malononitrile and ethyl cyanoacetate to yield isoxazol derivatives [3a, b]. The products are further modified to new isoxazol and its fused derivatives. Oximes of beta-ketoesters and beta- oxonitriles are versatile magnets which have been used as substrates for the synthesis of heterocyclic compound [1-3] which are of potential biological activities [4-6]. This work was described to extent synthetic routs to new isoxazol derivatives using malononitrile and ethyl cyanoacetate as active methylene reagents in reaction with oxime of ethyl acetoacetate
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Indice:
Méditerranée orientale
langue:
Anglais
Texte intégral:
Egypt. J. Chem.
Année:
1996
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