study on the effect of prostaglandin F2 alpha on blood glucose in normal, diabetic and stressed rats

ABSTRACT

The aim of the present work was to study the effect of prostaglandin F2 alpha on blood glucose level in normal and diabetic rats and to study its protective effect against stress-induced hyperglycemia and alloxan-induced diabetes. The results obtained showed that injection of prostaglandin F2 alpha reduced the ether stress-induced hyperglycemia, while it has no significant effect on plasma glucose level in normal and diabetic rats. The results showed that it has no protective effect against alloxan-induced diabetes. Interpretation of these results suggested that prostaglandin F2 alpha might act through stimulation of insulin release