Relation between fungal species and T-cell function in patients with dermatophytosis

ABSTRACT

Fifty-seven patients suffering from dermatophytic skin infections were evaluated clinically as well as mycologically and subjected to numerical evaluation of T-cells by E-Rosette method and functional evaluation of T-cells by blast transformation assay using phytohemoagglutinin. Trichophyton rubrum was the most prevalent isolated fungus [40.3%]. No growth was noticed in 3 cases. The results showed no significant difference [P >0.05] between normal controls and patients infected with dermatophytosis as regards T-cells percentage by E-Rosette and T-cell blast transformation except in patients infected with Trichophyton schoenleinii [P <0.05]. In conclusion, the study of cell-mediated immune response is of a value in the assessment of dermatophytosis