Study of thyroid status in Down Syndrome patients, a biochemical background

ABSTRACT

The aim of this study was to evaluate thyroid status in patients with Down syndrome in an early period [four months to three years]. This study comprised 71 children with Down syndrome diagnosed initially on clinical grounds. The diagnosis was confirmed by chromosomal studies using Giemsa- trypsin banding technique. Fourteen cases showed a significant increase in serum TSH levels compared with the control and other Down syndrome patients, while T4 levels showed no significant difference between patients and controls as well as between euthyroid and hypothyroid patients