Toxicological profile of typical and atypical anti-psychotic drugs in psychotic disorders

ABSTRACT

To evaluate the safety of antipsychotic drugs in psychotic patients. Randomized, comparative and categorical study. This study was conducted in the Department of Pharmacology, Faculty of Pharmacy, University of Karachi collaboration with Sir Cows Jee Jehangir Institute of Psychiatry Hyderabad and duration of study 1[st] Nov. 2007 to 3[rd] Jan. 2008. Patients were selected from OPD, Male and Female wards of Sir Cows Jee Jehangir Institute of Psychiatry Hyderabad. Total two hundreds patients were enrolled in the study out of them 192 patients continue through out study and eight lost follow up the study. The side effects were noticed according to UKU side effect scale. Same criteria was followed for both drugs in the study, assessments was done on the 07, 14, 28 and 42 days. Adverse effect of two drugs presented rigidity and tremors were the most common adverse effect in halopenridol 14.6% and 12.5% and in Risperidone 4.2% and 4.2% respectively. Overall Risperidone in our study proved efficacious and economical drug in psychotic patients. On the other hand haloperidol was also effective and cost effective but produced more side effects. Overall Risperidone in our study proved less toxic and cost effective drug in psychotic patients, on other hand halopendol was also effective and economical drug but should be more side effects