Immunohistochemical expression of CD20, CD43, and CD79 in Burkitt's lymphoma

ABSTRACT

Burkitt's lymphoma was reported as a distinct clinicopathological entity, it is a malignant and lethal condition that affects children between 2 and 8 years of age presenting as a massive growth in one or both sides of the maxilla or the mandible, in the molar-premolar region with loosening of the deciduous teeth or with premature eruption of permanent teeth. This study aims to evaluate the immunohistochemical expression of CD20, CD43, and CD79 in Burkitt's Jaw Lymphoma in relation to clinicopathological findings. Seven children [6 boys and 1 girl] aged 4-6 years old who were examined at Department of Oral and Maxillofacial Surgery, College of Dentistry, Anbar University and were investigated to correlate between clinicopathological findings of Burkitt's lymphoma using histopathological examination including imprint cytology, H and E and immunohistochemical expression of CD20, CD43, and CD79. The maxilla involved in all cases, the mandible in 2 cases, while the abdomen and viscera involved in 1 case only. The tumor cells showed lymphoblastic cells, with a uniform degree in cell size and cell maturity, darkly stained due to high content of ribonucleic acid [RNA] and cytoplasmic vacuoles due to high content of lipid and under light microscope; the tumor composed of small round cells interspersed with histocyte as starry sky appearance; while Immunohistochemical expression was done by evaluation of CD20, CD43, and CD79 expressions; The immunohistochemical staining using CD20, CD43, andCD79 monoclonal antibodies is a principal laboratory aids has a considerable value in the diagnosis and characterization of Burkitt's lymphoma, and they provide critical information for guiding clinicians to the appropriate treatment protocol for these malignancies