Pharmacokinetics and dosage regimen of ciprofloxacin following single intramuscular administration in Teddy goats

ABSTRACT

The objective of this study was to determine the pharmacokinetics and dosage regimen of ciprofloxacin in Teddy goats. Ciprofloxacin was administered intramuscularly at 5 mg/kg body weight in each of eight animals. Following drug administration, blood samples were collected at different time intervals and analyzed for ciprofloxacin using HPLC. Pharmacokinetic parameters were calculated using two compartment open model. Peak plasma concentration [C[max] of ciprofloxacin, 1.77 +/- 0.20 microg/ml was achieved at 0.90 +/- 0.04 hours [T[max]. Values for half-life of absorption [t [1/2] abs], distribution [t [1/2] alpha] and elimination [t [1/2] beta] were 0.52 +/- 0.04, 0.52 +/- 0.04 and 2.62 +/- 0.39 hours, respectively. The value for apparent volume of distribution [Vd] was 3.76 +/- 0.92 1/kg, area-under-the-curve [AUC] 5.89 +/- 0.91 microg.hr/ml and total body clearance [CL] was 1.09 +/- 0.11 1/hr/kg. Based on these results, it was concluded that calculated dose should be higher than the dose recommended by the manufacturer to treat susceptible bacteria in goats