[Treatmentofsteroid-esistantidiopathicnephrosiswithimmunosuppressivetherapy in 30 children]
Revue Maghrebine de Pediatrie [La]. 2008; 18 (2): 67-75
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| ID: emr-108758
ABSTRACT
The aim of this study is to evaluate the efficacity of immunosuppressive therapy in steroid - resistant idiopathic nephrotic syndrome. 30 children present to the renal biopsy a focal and segmental glomerulosclerosis [HSF 18 cases], minimal change disease [LGM 9 cases] and diffuse mesangial proliferation [PMD 3 cases]. 9 of 11 patients did not respond to cyclophosphamid. 28 patients received the cyclosporine - prednisone combinaison with a cyclosensibility in 23 patients [80 per cent]. The mycophenolate mofetil [MMF] was used in 7 patients, and 3 were in remission. In this study 7 patients [23 per cent] develop a chronic renal failure. the cyclophosphamid has not beneficial effects. The cyclosporine is an effective therapeutic agent. MMF has emerged as an important new therapeutic option for the treatment of SNCR and HSF
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Indice:
Méditerranée orientale
Sujet Principal:
Stéroïdes
/
Résistance aux substances
/
Glomérulonéphrite segmentaire et focale
/
Enfant
/
Ciclosporine
/
Cyclophosphamide
/
Immunosuppresseurs
/
Acide mycophénolique
/
Néphrose
/
Syndrome néphrotique
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Français
Texte intégral:
Rev. Maghreb. Pediatr.
Année:
2008
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