Studies on the potentiation analgesic effect of phenytoin and ketorolac with pelitazocine using albino mice by eddy's hot plate method

ABSTRACT

The analgesic activity was tested by Eddy's hot plate method in albino mice using combination of Pentazocine [1 mg/kg] with Phenytoin [10.20 mg/kg] and Pentazocine [1 mg/kg] with Ketorolac [10.20 mg/kg] was given by intra-peritoneal administration, The results showed a significant increase in reaction time [analgesia] in albino mice and hence the present study indicates that combination of Phenytoin and Ketorolac with Pentazocine has significant prolonged analgesic effect as compared with analgesic effect produced by Pentazocine alone