Assessment of phytochemical and pharmacological activites of Anisomeles indica leaves

ABSTRACT

The leaves of Anisomeles indica was tested for its antioxidant, analgesic, and antidiarrhoeal activities in experimental animals. The extract showed the presence of antioxidant principle qualitatively based on the scavenging activity of 1,1-diphenyl-2-picryl hydrazyl [DPPH] free radical. It showed the presence of antioxidant principle. The extract dose dependently inhibited the acetic acid induced writhing in mice [63.05%, P<0.001 and 37.63% for 500 and 250 mg/kg body weight respectively], the effect was significant comparable to the standard drug Diclofenac Sodium [54.92%, P<0.001] at the dose of 25 mg/kg. The extract of A. indica offered about 1.20 hrs and 3.7 hrs [P<0.001] of the mean latent period for diarrhoeal episode at the doses of 250 and 500 mg/kg body weight which is comparable to standard drug Loperamide. The results tend to suggest that the leaves might possess analgesic, antioxidant and antidiarrhoeal activities or active constituent[s] responsible for the activities and supported its traditional uses