Hepatoprotective and therapeutic effect of Muravvaq of Mako on rifampicin-induced hepatotoxicity in rats just after rainy season [August-September]

ABSTRACT

The efficacy of Muravvaq of Mako [Frothless juice of Aolanum nigrum leaves] to control hepatic damage induces by Rifampicin was studied in Wistar albino rats. Rifampicin was administered orally as suspension to rats with a daily dose of 50 mg/kg body weight till 30 days with Muravvaq of Mako in concurrent group. In the second phase of study the effect of Muravvaq on established hepatotoxicity was studied by giving it for 20 days after withdrawal of Rifampicin. Hepatic dysfunction was assessed by biochemical and histological parameters. A significant increase observed in serum bilirubin, SGOT, SGPT and Alkaline phosphatase levels in negative control groups. However, there was a significant reduction in increased enzymatic levels in concurrent and treated group of rats, which received Muravvaq alongwith Rifampicin for 30 and 50 days, respectively. Histopathological analysis of liver samples also confirmed the hepatoprotective effect of Muravvaq. These results suggest that Muravvaq of Mako shows hepatoprotective effect against Rifampicin-induced hepatic damage in rats. The study was done in two different seasons, just after rainy [August-September] and in autumn season, to assess the efficacy of seasonal variation