Effect of methanol extract of panicum repens and cestrum parqui on some liver enzymes in schistosoma mansoni infected mice

ABSTRACT

The effect of methanol extract of Panicwn repens and Cestrum parqui on the infectivity of mice with S. mansoni cercariae and some liver enzymes in S. mansoni infected mice representing glycolytic, gluconeogenic and glycogenolytic pathway and also, liver function enzyme represented by Aspartate aminotransferase [ASAT], alanine aminotransferase [ALAT], acid phosphatase [ACP] and alkaline phosphatase [ALP] were studied. The present results showed that a significant reduction in number of worm and ova count of infected mice pretreated with P. repens and C.parqui. The present results showed that a significant increase in glycolytic enzymes [PK, GPI and HK], acid phosphatase [ACP] and alkaline phosphatase [ALP] were observed in both infected and treated infected groups, while lactate dehydrogenase [LDH], aspartate aminotransferase [ASAT] and alanine aminotransferase ALAT enzymes activities showed significant reduction. Moreover, normal control mice treated with methanol extract of P. repens and C parqui showed no side effects of most parameters compared to the normal healthy control group. Hence, methanol extract of P. repens and C.parqui can be applied clinically as a prophylactic treatment against schistosomiasis together with the ideal anti-schistosomal drug praziquantel