NGF and PTH relationship to peripheral nerve function in uremic patients

ABSTRACT

Nerve growth factor [NGF] parathormone hormone [PTH], and electro physiological study of peripheral nerve have been evaluated in 40 uremic patients with mean age 38.7 +/- 3.6 years, 23 males, 17 females versus 40 normal control subjects with mean age 38.6 +/- 3 years, 25 males and 15 females. NGF was significantly lower in uremic patients than control group [69+32, 48 +/- 12 ng/ml], respectively, p<0.001. Patients of long term chronic renal failure [CRF] have significant lower values of nerve conduction velocities, amplitude of sensory and motor action potential with prolonged distal latency than those of short term one, p<0.001. Dialyzed patients have significant reduced sensory and motornerve functions than non-dialyzed-one, p<0.001. NGF was significantly lower in dialyzed group than non-dialyzed one [44 +/- 19, 97 +/- 17 ng/ml], respectively, p<0.05. NGF showed significant negative [+ve] correlation to PTH values, p<0.01. NGF showed significant-ve correlation to the duration of CRF and dialysis therapy and significant positive [+ve] relation to peripheral nerve functions p<0.01. PTH values exhibited+ve correlation to the duration of CRF and dialysis therapy with-ve significant relation to peripheral nerve functions, p<0.01. NGF in concordance with PTH-seem to have significant role on the degree of peripheral nerve dysfunction among uremic patients