Hyperhomocysteinemia and cardiovascular diseases in Algeria people

ABSTRACT

Epidemiological research has shown that elevated total homocysteine [thcy] is a risk factor for atherosclerosis disease. This study was carried in symptomatic patients with cardiovascular disease n= 63 and asymptomatic n= 27. There was a significant decrease in Total-cholesterol [3.65mmol/l +/- 1.25] and HDL-cholesterol [0.84mmol/l +/- 0.48] in symptomatic patients and compared with asymptomatic the concentration of Total-cholesterol was [4.12mmol/l +/- 0.84] and HDL-cholesterol was [1.17mmol/l +/- 0.54]. The concentration of enzymes LDH, CK and ALP [271.47units/l +/- 129.18, 121.34units/l +/- 142.50 and 232.57units/l +/- 95.72], respectively in symptomatic patient and in asymptomatic control group were [170units/l +/- 46.3, 74.3units/l +/- 38.5 and 50 and 132.73units/l +/- 59.81], respectively, these values are increased significantly between two groups. The main values of thiols [homocysteine; cysteinylglycine, glutathione oxidized and reduced] were higher in patients with cardiovasculardisease [10.21micro mol/l +/- 5.59, 32.38 micro mol/l +/- 22.34, 17.91 micro mol/l +/- 8.83 and 32.96 micro mol/l +/- 17.34], respectively than in asymptomatic subjects where the concentration of thiols were [7.67 micro mol/l +/- 2.66, 25.48 micro mol/l +/- 11.11, 6.66 micro mol/l +/- 2.79 and 12.09 micro mol/l +/- 5.18]. The main value of homocysteine [12.89 micro mol/l +/- 4.59] was increased highly and significantly in symptomatic postmenopausal women in contrast to homocysteine concentration [8.45 micro mol/l +/- 4.94] in male patients. Our study suggests that plasma level total homocysteine is an independent risk factor in atherogenic process