Your browser doesn't support javascript.
loading
Formulation and pharmacokinetic study of ranitidine hydrochloride suppositories
Journal of Drug Research of Egypt. 2008; 29 (1): 9-16
Dans Anglais | IMEMR | ID: emr-112297
ABSTRACT
The present work is an extension of previous effect of certain excipients on the bioavailability of ranitidine hydrochloride. It was concluded that sodium sulphate ranitidine hydrochloride mixture in ratio 11 in both physical and coground mixtures are the excipient of choice for overcoming the hygroscopic nature of ranitidine. Also, statistical analysis of the pharmacokinetic data revealed that coground mixture gave more relative bioavailability than the physical mixture. Influence of the hydrophobicity of different fatty suppository bases on the dissolution profile of ranitidine hydrochloride coground mixture was studied. Witepsol W[25], W[3], and W[35] either single base or blends in [11] w/w ratio were used as hydrophobic suppository bases. Weight variation, content uniformity, hardness and melting range tests were conducted on the formulations. In vitro release was carried out according to USP basket method. Shelf storage of bases showing the highest drug release namely Witepsol W[25], W[25]+W[35], W[25]+W[31], showed no significant change in the drug release. Witepsol W[25] was subjected to in-vivo availability study as representative of the most promising formula according to the in vitro release data. The in-vivo availability and pharmacokinetic studies of the selected formula as well as on the oral administration of commercial product and coground mixture to act as reference product revealed that for practical use the dose of suppositories should be 60% of the oral dose of coground mixture according to AUC[0-6] values
Sujets)
Recherche sur Google
Indice: Méditerranée orientale Sujet Principal: Lapins / Suppositoires / Administration par voie rectale / Chimie pharmaceutique / Administration par voie orale Limites du sujet: Animaux langue: Anglais Texte intégral: J. Drug Res. Egypt Année: 2008

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS

Recherche sur Google
Indice: Méditerranée orientale Sujet Principal: Lapins / Suppositoires / Administration par voie rectale / Chimie pharmaceutique / Administration par voie orale Limites du sujet: Animaux langue: Anglais Texte intégral: J. Drug Res. Egypt Année: 2008