[ association between hyperemesis gravidarum [HG] and helicobacter pylori [H.pylori] infection]

ABSTRACT

HG is a severe form of expectancy nausea and vomiting, occurring in 0/5 to 2% of the expectancies. The etiology of HG is unknown, though hormonal stimuli, and psychologic predisposition are attributable to the condition. Recent studies suggest a relationship between HG and H.pylori infection. The aim of this study was to investigate the relationship between HG and H.pylori infection. Forty pregnant women with HG [Treatment group] and forty asymptomatic pregnant women [control group] were assigned into the research from April to August 2006. Specific serum immunoglobulin G [IgG] for H.pylori was assayed by ELISA. The data was analyzed using SPSS software, Chi-Square and T-test. Out of 40 pregnant women with HG 25 individuals [62/5%] were found to have serologically positive H.pylori, whereas in asymptomatic pregnant women 19 [47.5%] individuals were positive, which shows no significant difference between H.Pylori infection with HG [P=0.178]. No significant difference was observed between positive H.pylori and the number of pregnancy, body mass index [BMI], and duration of hospital stay. Since HG has a multifactorial etiology and with regard to high prevalenve of H pylori in our country, research studies with higher sample sizes and utilization of more sensitive diagnostic methods for the detection of active H pylori is recommended