Association of sterile pyuria and coronary artery aneurysm in Kawasaki syndrome

ABSTRACT

Kawasaki disease [KD] is an inflammatory multiorgan disease of unknown etiology. The most dramatic organ involved is the heart. There were a few studies about cardiac involvement and sterile pyuria. This study guides to determine if sterile pyuria is associated with coronary artery aneurysm [CAA] in KD patients and to consider it as a predicting factor for coronary artery involvement. Forty seven patients with KD were studied by echocardiography in admission and one month later. Urine analysis, complete blood count, erythrocyte sedimentation rate and C-reactive protein were measured in admission. Data were analyzed using SPSS-14 software. Patients' age was ranged from 13 month to 7 years old [mean age of 3.43 +/- 1.54 years]. Thirty patients [63.8%] were male and 17 patients [36.1%] were female. Cardiac involvement was detected in 32 patients [68%] using echocardiography, of which CAA was reported in 8 cases [17%]. Six of CAA [75%] were in association with sterile pyuria, although it was statistically insignificant [P>0.05]. Although the majority of patients with CAA had sterile pyuria, this association is not statistically significant, thus it couldn't be considered as a predicting factor for CAA