Ethanol induced hepatotoxicity in albino rats
JCPSP-Journal of the College of Physicians and Surgeons Pakistan. 2011; 21 (10): 642-643
Dans Anglais
| IMEMR
| ID: emr-114253
ABSTRACT
Twelve male albino rats of 6-8 weeks old, weighing 150-200 gm each were divided into two groups of 6 rats each. Group A was used as control while Group B was given ethanol at a dose of 0.6 ml [0.5 gm]/100 gm/day for 8 weeks. Serum enzymes and liver histology was determined in both groups. Statistically significant increase in the mean enzyme levels, liver weight and volume were observed in the ethanol treated group compared to the controls. Histologically, hepatocytes contained large number of cytoplasmic vacuoles, pyknotic nuclei, and lymphocytic infiltration in treated animals. Ethanol appeared to be hepatotoxic in albino rats
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Indice:
Méditerranée orientale
langue:
Anglais
Texte intégral:
J. Coll. Physicians Surg. Pak.
Année:
2011
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