Comparison of bio-availability of different brands of chloramphenicol currently on the market

ABSTRACT

Different drug manufacturers claim better qualities and bioavailability of their products as compared to identical strengths of these very drugs manufactured by their rivals. In view of this confusion, bioavailability of four different brands of chloramphenicol was measured in ninety six albino rabbits. The relative bioavailabilities were determined by measuring area under curve [AUC] of plasma concentrations versus time which were 100%, 85.34%, 76.14% and 83.83% for the brands A, B, C, and D respectively. However, the plasma concentrations remained well above [4-5 times] the minimal inhibitory concentrations [MIC] against sensitive organisms for a reasonable period of time with all the four brands. Therefore, we presume that they should not differ in their clinical efficacies