Role of glycemic control and blood pressure in the development of microalbuminuria in NIDDM patients

ABSTRACT

To assess the relationship of elevated urinary albumin excretion to glycated hemoglobin and increased blood pressure in non-insulin-dependent diabetic patients. Analysis of glycated hemoglobin, blood pressure, serum and urinary creatinine, body mass index in groups I, II and III, i.e., 21-120, 1 21-170 and 171-200 micro g/min, respectively, based on rate of albumin excretion in 24 hours urine samples of patients with NIDDM. Department of Biochemistry, Basic Medical Sciences Institute and Diabetic Clinic of Jinnah Postgraduate Medical Centre, Karachi. A total of one hundred patients having NIDDM diagnosed at least two years previously and 25 apparently healthy subjects as control with similar socioeconomic status were selected. Serum glycated hemoglobin, urinary albumin, albumin creatinine ratio and creatinine clearance were significantly increased in all groups when compared to controls, whereas systolic blood pressure of group-Ill was highly significant. The results of this study prove the effect of poor glycemic control and increased blood pressure on development of microalbuminuria in NIDDM patients