Influence of age and gender on association between -765G > C COX-2 genetic polymorphism and gastric adenocarcinoma risk: a case- control study in Iran

ABSTRACT

The purpose of this study was to investigate the possible influence of age and gender on association between - 765G > C COX-2 genetic polymorphism and gastric adenocarcinoma risk in Iranian patients. The promoter polymorphism of COX-2 gene -765G>C has been described to play an important role in many cancers such as gastric cancer. We carried out single-nucleotide polymorphism analysis in Iranian samples including 91 patients and 91 control normal using PCR-RFLP technique. Statistical analysis revealed no significant association between GG, GC and CC genotypes and risk of gastric adenocarcinoma. However differences were considered significant [P=0.043] for female subjects with C carrier genotypes [GC and CC] and gstric adenocarcinoma when compared with male patients [P=0.645] and control groups [P=0.653]. Also, there was a statistically significant difference between increasing of age and susceptibility for gastric adenocarcinoma [Odd Ratio = 1.125, 95% CI=1.089-1.162]. These results suggested that Iranian C carrier females can be more susceptible for gastric adenocarcinoma in comparison with control group. Also increasing of age should be considered as a risk factor for this disease