Pharmacokinetics for dose proportion; estimation of 250 mg cefaclor tablet in male volunteers
Professional Medical Journal-Quarterly [The]. 2010; 17 (4): 706-710
Dans Anglais
| IMEMR
| ID: emr-118025
ABSTRACT
To estimate dose proportion for male volunteers by calculating pharmacokinetics following oral administration of Cefaclor [CCL] 250mg Tablet and to check the relative susceptibility of four bacterial strains. Randomized Clinical Trial, case series. Department of Chemistry and Biochemistry, University of Agriculture, Faisalabad. From Mar 2006 to Feb 2007. Blood samples were collected for the period of 12 hours in heparinized tubes. Collected samples were centrifuged at 3000xg and plasma thus separated was stored at -10°C until further analysis. The CCL plasma concentration was determined via bioassay using disc diffusion method. Pharmacokinetics parameters were calculated using American Pharmacology Organization [APO] computer software. Renal Clearance [CL], volume of distribution [VD], time of Peak [T[max]], maximum plasma concentration [C[max], mean residence time [MRT], absorption half life, elimination half life and the Area Under plasma Concentration [AUC [t0tot12h] showed that the four bacterial strains have different susceptibility against cefaclor and administration of cefaclor at rate of 250 mg as tablet orally thrice daily maintained considerable concentration [>MIC] that prove it to be very effective for the treatment of specific infections in male volunteers
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Indice:
Méditerranée orientale
Sujet Principal:
Bénévoles
/
Dosage biologique
/
Tests de sensibilité microbienne
/
Administration par voie orale
Type d'étude:
Essai clinique contrôlé
Limites du sujet:
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Professional Med. J.-Q
Année:
2010
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