Antiprothrombin autoantibodies in patients with pre-eclampsia

ABSTRACT

Sixty women in their third trimester were included in this study. They were divided to three groups Group I Included 30 pregnant women with documented Pre-eclampsia. Group II Included 20 normotensive women with uncomplicated pregnancy. Group III included 10 healthy non-pregnant women. There was highly significant difference as regards weight of the newborn between patients with Pre-eclampsia and normal pregnant group [with mean value of 2792.3 gm and 3436.8 gm respectively]. There was no significant difference as regards hematological data [Hb, platelet count, PT and PTT] between the three studied groups. There was highly significant difference as regards antiprothrombin IgG antibody between the three studied groups [with a mean value of 18.8 U/ml in patients with Pre-eclampsia, 6.5 U/ml in normal pregnant women and 3.1 U/ml in non pregnant women]. There was highly significant difference as regards antiprothrombin IgM antibody between the three studied groups [with a mean value of 27.1 U/rnl in patients with Pre-eclampsia, 11.5 U/ml in normal pregnant women and 3.6 U/ml in non pregnant women]. There was also strong positive correlation between weight of the newborn in patients with Pre-eclampsia on one hand and PT, PTT, ALT, AST, uric acid antiprothrombin IgG and IgM antibodies on the other hand. There was strong positive correlation between the level of antiprothrombin IgG in patients with Pre-eclampsia on one hand and blood pressure, PT, PTT, platelets, ALT, AST and uric acid. There was strong positive correlation between the level of antiprothrombin IgM in patients with Pre-eclampsia on one hand and blood pressure, PT, PTT platelets, ALT, AST and uric acid. There was also strong positive correlation between the levels of antiprothrombin IgG antibody and that of antiprothrombin IgM antibody in all studied groups. There was strong positive correlation between the levels of antiprothrombin IgG and IgM antibodies and the severity of Pre-eclampsia. There were no similar correlations found between the levels of antiprothrombin IgG and IgM antibodies in either normal pregnant women or non pregnant women and different studied parameters. The level of antiprothrombin IgG and IgM antibodies was higher in patients with Pre-eclampsia and it correlates well with different clinical and laboratory data and the severity of Pre-eclampsia