[Investigation of interferon-gamma receptor-1 polymorphism in Iranian patients affected with pulmonary tuberculosis]

ABSTRACT

Tuberculosis is one of the most common infectious diseases in the world. In recent years, genetically approach has been developed. One of the interesting gene for investigator is IFN- gamma R1. In this study we determind susceptibility to tuberculosis with polymorphism of IFN- gamma R1 gene. Fifthly patients with smear positive tuberculosis have been chosen randomly. They were matched with 54 healthy controls with no history of TB. Polymorphism at 395 codon of IFN- gamma R1 gene was detected with Newport method. Mean age of patients and control were 55 13.5 years respectively. Demographic characteristic had no +/- 20 and 53 +/- difference within two groups. One patient in case group had heterozygote mutation at IFN- gamma R1 gene. In control group there were no mutations. Genetically susceptibility to TB was not seen in 395 colon of IFN- gamma R1 in Iranian TB sample and polymorphism of this loci has occur in 2% of TB patients and 0.96% of total study population