[Clinical and etiological features of primary adrenal insufficiencies in children]
Tunisie Medicale [La]. 2008; 86 (10): 890-894
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| ID: emr-119742
ABSTRACT
The chronic primary adrenal insufficiency or Addison's disease is uncommon in children and belongs generally to a complex syndrome. Study of the clinical and aetiological features of primary adrenal insufficiencies in children. In a retrospective study, we reviewed clinical and diagnostic data of all cases of Addison's disease admitted within a period of 15 years [from January 1991 to December 2006], in a department of paediatrics. Cases due to congenital adrenal hyperplasia were excluded. 6 cases of Addison's disease were diagnosed. Five patients are the product of consanguineous marriage. The age at the diagnosis of adrenal insufficiency yarned from 15 months to 9 years 8 months. The adrenal insufficiency was associated to Allgrove syndrome in three cases, to autoimmune polyendocrinopathy type 1 in one patient and to probable peroxisomal disease in another one. The etiological disease was not determined in one patient. A substitutive hormonal therapy was conducted in all patients. During a mean follow-up of 26 months, two adrenal crises were noted. larger studies about Addison's disease are needed to confirm the preponderance of the Allgrove syndrome
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Indice:
Méditerranée orientale
Sujet Principal:
Maladie d'Addison
/
Enfant
/
Études rétrospectives
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Français
Texte intégral:
Tunisie Med.
Année:
2008
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