Systolic time intervals before and after therapy in moderate hypertension

ABSTRACT

Twenty with moderate hypertension [diastolic pressure 105 mm Hg-115 mm HG] were studied to assess the cardiac performance before and after therapy using STI, patients were devided into two groups where group I received combined triple therapt [0.1 reserpine, 25 mg hydralazine, hydrachlorothiazide 15 mg] in single tablets, group II received capoten 75 mg in divided doses, to compare the efficiency of single drug therapy and combined triple therapy. 10 normotensives were also included as control. It was found that left ventricular performance was significantly impaired in hypertensive patients before therapy without any evidence of heart failure. After therapy B.P fell significantly in both groups, more so in the first, the difference between the reduction of the mean pressure in the two groups was significant; left ventricular performance improved significantly in the first group only