Sister chromatid exchange and carcinoembryonic antigen in cigarette and Hubbell-bubble smokers: Effects of halothane anesthesia and extradural bupivacaine analgesia

ABSTRACT

The study was done on 80 adult males, chronic cigarette and hubble- bubble smokers. They were scheduled for minor and moderate lower abdominal surgery under either halothane anesthesia or extradural bupivacaine analgesia. They were premedicated by pethidine 2 mg/kg and hyoscine 0.5 mg i.m. 6 ml of venous blood were sampled at different time intervals for total leucocytic count, lymphocytic percentage, sister chromatid exchange in lymphocytes [SCE] and plasma carcinoembryonic antigen [CEA] level. Significant leucocytosis with lymphocytopenia was noticed among smokers in the two tested groups. Insignificant increase in SCE and CEA were obtained in smokers under both halothane anesthesia and extradural bupivacaine analgesia