Calcium and prostaglandins in blood and uterine muscle in normal and abnormal uterine actions

ABSTRACT

Uterine activity integral [UAI] together with plasma and uterine muscle calcium ions, PGF2 alpha and PGE2 were estimated in 32 primigravidae of those admitted to the Department of Obstetrics and Gynecology of El-Menia University Hospital and delivered by cesarean section. Seven women showed normal uterine action, 15 showed hypotonic uterine action, and 10 showed hypertonic uterine action. The study showed that PGE2 alpha and calcium ions levels increased in blood and uterine muscle during labor, especially in the hypertonic state and decreased in the hypotonic contractions, whereas, PGE2 showed no significant changes. These changes could incriminate PGF2 alpha and calcium ions in the pathogenesis of these abnormal uterine actions