Plasma level of soluble thrombomodulin in acute myocardial infarction and acute ischemic stroke in type 2 diabetes mellitus

ABSTRACT

The present study was carried out on 40 patients with acute myocardial infarction [AMI] or acute ischemic stroke [AIS]. The patients were divided into four groups [each group comprised ten patients] Group I included nondiabetic patients with AMI, group II included diabetic patients with AMI, group III included nondiabetic patients with AIS and group IV included diabetic patients with AIS. In addition, ten healthy subjects were taken as a control group. Mean plasma soluble thrombomodulin [sTM] level was significantly lower in patients with AMI [group I + group II] [3.88 ng/ml + 3.8] and in patients with AIS [group III + IV] [3.75 ng/ml + 2.8] compared with the control group [6.64 ng/ml + 2.33] with no significant difference between patients with AMI and AIS. Acute myocardial infarction [AMI] and acute ischemic stroke [AIS] were associated with decreased plasma sTM, reflecting the decreased expression of endothelial TM, thus disturbing the balance between procoagulant and anticoagulant factors towards a pro-coagulant state. In patients with AIS, diabetics have lower plasma sTM than non-diabetics