Five-year follow-up of the local autologous transplantation of CD133+ enriched bone marrow cells in patients with myocardial infarction
Archives of Iranian Medicine. 2012; 15 (1): 32-35
Dans Anglais
| IMEMR
| ID: emr-122407
ABSTRACT
The implantation of a CD133+ bone marrow cell population into an ischemic myocardium has emerged as a promising therapeutic modality for myocardial regeneration and restoration of ventricular contractility. While previous studies have documented the short-term safety and efficacy of CD133+ cell transplantation in patients with acute myocardial infarction, there are few reports of long-term follow-up results. Here, we present the results of long-term follow-up of our acute myocardial infarction patients who were treated with intra-myocardial injection of CD133+ cells after coronary bypass graft. After five years, 13 patients in the cell transplantation group and 5 patients in the control group underwent safety and efficacy investigations by New York Heart Association classification and two-dimensional echocardiography [2D echo]. During the five-year study period, no major cardiac adverse events were reported among patients who received CD133+ stem cells. Regarding efficiency, we observed no statistically significant treatment effects for the echocardiographic parameters [left ventricular end-diastolic and end-systolic volumes, and resting ejection fraction] measured during the follow-up period. However, detailed analysis of regional wall motion revealed an improvement in the Wall Motion Score Index from baseline to the six month follow-up, which was maintained during the follow-up period. Taken together, the long-term results of the present study indicate that transplantation of CD133+ is a safe and feasible procedure; however, we could not show any major benefits in our patients. Thus, this issue needs to be addressed by conducting other studies with more patients
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Indice:
Méditerranée orientale
Sujet Principal:
Peptides
/
Transplantation autologue
/
Échocardiographie
/
Glycoprotéines
/
Antigènes CD
/
Pontage aortocoronarien
/
Études de cohortes
/
Études de suivi
/
Infarctus du myocarde
Type d'étude:
Etude d'incidence
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Arch. Iran. Med.
Année:
2012
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