Comparison between sublingual misoprostol and intramyometrial prostaglandin F2A in adjunct to routine management of primary postpartum hemmorhage

ABSTRACT

To study the efficacy of sublingual misoprostol as compared with injectable PGF2alpha in management of primary Post Partum hemorrhage [PPH]. Randomized controlled trial. Combined Military Hospital Risalpur, from January 2006 to September 2008. All patients who reported to CMH Risalpur were included except women with previous cesarean section and those with gestational age less than twenty eight weeks at the time of delivery. They were randomized in two equal groups of thirty patients each. One group received 600mcg sublingual misoprostol [Parke-Davis] combined with standard oxytocic treatment and the other group received intramyometrial PGF2alpha [Prostin F2alpha, Dinoprost- Parke-Davis] combined with standard oxytocic for treatment of primary PPH. There was insignificant difference between both groups in terms of blood loss [p>0.05], treatment failure [p=0.640] and side effects [p=0.05]. Sublingual misoprostol was found to be equally effective as compared to intramyometrial PGF2 alpha for the treatment of primary PPH but superior when price, availability and storage are taken into account